Actually, for many, the *first* tweaks in their system. I can't believe how many new things we have, for our systems.
AC power conditioners and on-site generators. These were rare in audio, as recently as the 1990's. Now it's hard to find an audiophile without them - they work.
RF noise removers - like the Nordost QX4 and Acoustic Revive's devices. Effectiveness may vary - but Art Dudley really liked the Nordost, at least in his system.
"1F" noise removers. A theory says that electrons get jammed in the signal path - and people like Jack Bybee and Bob Smith (w/ NuForce) are doing something about it. Most of us never heard of this type of noise but apparently, it was introduced to the music signal-path.
Power supply noise. Bybee again - but this time he stands alone with his new "Music Rails". Power supplies were always high on the blame-list in robbing us of musical detail. So it makes sense that the issue is being tackled aggressively. These are just coming out, but first reports say they are a major advance in sound.
Room "conditioning" products. Audiophiles are scratching their heads as to how they work - but again, reports say they are *not* snake oil. Passive products ("resonators", the "Hallograph") and active (SteinMusic and Lessloss "Blackbody") are making a difference in many audiophile rooms.
I guess the era of room "treatment" and floor-cable lifters is over - we are awash in a new world of tweaks.....